elrico

LemmingInvestors Small Cap – research articles

OptiBiotix Health New Zealand Partner – PharmaBiota

On Thursday 30th May I had a rather long chat with Peter Lagan, CEO of New Zealand based PharmaBiota. Peter discussed his background in the pharmacy, his passion for probiotics, something Peter had put off developing for 15 year due to other projects. The the probiotic fire was stoked when he hooked up with OptiBiotix Health (OPTI) at the Berlin Porbiota nutritional conference in 2017. He watched with interest CEO of OPTI, Stephen O'Hara delivering the LP-LDL abstract. It's clear from the conversation Peter feels the prebiotic and probiotic markets are going to be significant drivers in human health. Peter's passion for the nutritional health benefits was very evident, he spoke at great length about his experience and looks to the future with excitement.

Q: Pete, can you explain to me how you became involved with OPTI, you are after all from the Southern Hemisphere. A: As pharmacist with 35 years interest in health supplements and in probiotics for the last 15 years, I saw SOH at Berlin Probiota conference in 2017. SOH's delivering the LP-LDL abstract and afterward discussing one on one, impressed me greatly.

Q: We are now approaching a year since the agreement, so naturally I'm wondering what the process is and if you are on schedule to launch of your cholestero-Biota A: There had been a delay in launch as I have been busy, being busy. The final formulation wasn't formalised until November, some time after the initial agreement. Peter stressed this was not OPTI's fault, but due in part to business commitments and in part the as NZ regulatory body Medsafe whom were keen to ensure it was a dietary supplement ( and not a medicine ). With an effective product it is sometimes a fine line between it having medical actions and not making claims to those actions overtly.

Q: When can we expect the products to be publicly available A: We took delivery of the products end of April. We are now in the process of a client (pharmacists) B2B marketing campaign, which I will keep low key initially and have the market driven from pharmacist to consumer rather than the reverse . The products are in the market now, it's been with the wholesaler for the past week. We are finalising promotional documentation.

Q: Does the NZ regulatory protocol , if categorising LP-LDL as a medicine, make it more expensive than OTC supplement A: Yes, it is hugely more expensive. Currently , however to sell over the counter LP-LDL. We aim for a $1 a day whereas you get state subsidised medicines for $5 for 90 days supply. If you are making a claim (medical) straight away legislative costs would make it unrealistic.

Q: Can you confirm your products will be an OTC dietary supplement A: Yes, and I will encourage pharmacists and senior pharmacy staff to oversee the initial sales

Q: As well as offering different doses, do you plan to have a combi products for Cholesterol and Hypertension A: This would be difficult regulatory hurdle to target hypertension and as mentioned , any medical claims are not allowed unless you license as a medicine. NZ has tough regulatory structures. (I think Peter was suggesting this is claiming for hypertension is not on the immediate horizon because he has enough with existing products. Cholesterol “support” however is a softer target).

Q: What level of sales volume are you anticipating in the first 12 months A: It is very difficult to gauge the level of interest at an early stage. There could be a slower take up, not the quick “honeymoon” stage as there often is with new glossy magazine advertised products. The LP-LDL will become more established due to effectiveness, patient acceptance and word of mouth. We are looking long term effectiveness. (This is of course consistent with SOH stance on guesstimating sales for new products with new science in new markets).

Q: I believe your market is primarily New Zealand & Australia, but I also believe you have a health and well being business in Singapore. Are there any plans to offer your LP-LDL products in other territories or does your license with OPTI restrict this. A: Singapore is not me. Primary market is NZ and am planning to launch in Australia. The regulatory system ( TGA Therapeutics Goods Act )in Australia is a little different again.

Q: Do you have any ambitions to use SweetBiotix or LPGOS in the future A: Absolutely yes, I like OPTI's three main products and see a business development, especially for SlimBiome products in particular in the future.

Peter talks of OPTI and SOH as a great business, a smart businessman and business model, licensing their IP as being a smart move. It is akin to owning a large tower block and renting the space out to your clients and your clients needing to go out to work and earn their keep. I'm investing in their IP; ultimately if I succeed so does OPTI. The BOD are very clever guys with a great business.

OptiBiotix commercial progress for LP-LDL & SlimBiome Cholesterol, hypertension and weight management. SlimBiome is a multi award winner

Small Companies – £300k + pa (EACH) THWLC (GoFigure) SlimBiome (May 2017) HLH BioPharma – LP-LDL (May 2017) Germany and EU PharmaBiota – LP-LDL (September 2017) New Zealand & Australia

Medium Companies – £500k to £1m pa (EACH) Nutrilinea – LP-LDL (May 2017) EU Knightons – SlimBiome (November 2017) UK Cambridge Commodities – SlimBiome (April 2018) UK & EU Seed Health – LP-LDL (TBC)

Large Companies £1.5m + pa (EACH) SACCO – LP-LDL (August 2017) Global Galenicum – LP-LDL (October 2017) EU, Middle East, Japan, America's Cereal Ingredients Inc – SlimBiome (December 2018) USA TATA – SlimBiome (December 2016) ASIA TATA – LP-LDL (September 2017) India & Asia Tigren pharmaceuticals – LP-LDL (April 2018) Pakistan FineFoods & Pharmaceuticals -LP-LDL (March 2018) EU AKUMS – LP-LDL + LP-LDL pharmaceutical (May 2018) India & South Asia

Undisclosed US partner – SlimBiome (TBC) 3 large UK Retailers – (TBC) these could yield **£5m – £6m pa 2 global corps interested in using SweetBiotix Bened MOU cross partnership IP Asia & EU, USA

PLC costs under £1m pa – DO THE MATH Using below industry valuations of 10 time earning, for fun only, tweet a reply with your future valuation. I dare you!! :–)

Note: No additional cash injection required from OptiBiotix as commercial ramp up progresses.

The market is missing a significant NEW development with AKUMS announcement. As well as OTC products, AKUMS has the option to take OPTI LP-LDL IP down the pharma route. Given OPTI platform is pharma based and phase 3 ready, this save 6-8 years R&D saving millions in the process.

It's no coincidence these last 3 commercial agreements have been with pharma companies with a who's who client list within the pharma industry; Abbott, Novartis, P&G, Pfizer, Bayer, Sanofi and Sandoz.

IMHO these routes offer discrete back-door route to pharma commercial agreements.

Elric Lloyd-Langton 2nd September 2009

Market Maker Tactics

If there is one particular part of markets functions I think investors should learn more about, it would be how Market Makers work, their tactic and functions. Yes, we can get hung up on global and local markets, of course. However, there is surprisingly little known about this area as a topic, yet it’s importance is often misunderstood and ignored in equal measure. With the help of a little inside knowledge from and ex MM friend of mine; lets see if we can help explain their role a little.

Are they out to get you? Erh, not really, but they don’t care about you or the company either. They look after themselves and their broker clients. Like investors and traders, they can be caught on the wrong side of a market. However, unlike you and I, the MM can employ a number of tactics to get them out of a tight spot. Some perfectly legal, some morally questionable to the damn right illegal.

Orderly Market? It is the MM roll to know what is being discussed and what it news worthy related to the stocks they keep a book on, so it should be no surprise to learn they follow BB’s and press, etc. After all, knowing where the weak holders are, is meat and drink to the MM. Part of the roll is identifying the BBM or as I like to call them, lemming investors, sometimes referred as dumb money, a phrase coined stateside.

MM’s trading BBM stocks it is very easy for them to get trapped into being short in dealing in a fast moving market and or illiquid market because most MM's in this stock are what are called “wholesalers” this means they don't have retail brokers “working” the stocks. So they have to rely on what's known as the “call” from larger retail houses. If a “Big” retail firm like IG or E-trade calls to purchase say 10,000 shares of a stock, they expect to get an “execution” from that market maker. If he turns them down, or only gives a partial fill then the “Big” firm will go to another MM. If this second MM “fills the order” then that “Big” firm has a moral obligation (Yes, moral obligation….I know!) to continue to give future “business” in that stock to that MM whom did the business for them. This will go on until he “fails” to perform and so on. So the last thing a MM needs is to get a bad rep from a big boy in the city.

Popular Myth Contrary to popular opinion the “Big” firms Do NOT necessarily go to the “Low Offer” to fill a buy order (Or high bid for a sell). They “Go” to who they think will perform to fill the order and expect that MM to “match” the “low offer” in the case of a buy. Even though this MM might in fact be the “high bid” and not really want to sell any more. As a wholesaler he must perform or he will get a reputation as a “non-performer” with the “Big” houses and will cease getting “calls” which means he will soon go out of business. I mentioned above that this activity is very significant to BB stocks. I say this because most of the trades in these BB stocks are “unsolicited” and are done through discount houses.

With the above groundwork laid, let me try to explain how market makers get short even if they like the Company; Let’s say that a stock (A) has been lying quietly at 25p bid 50p offered. A limit order comes into one of the MM's to Buy at 50p for a 1000 shares. Prior to this trade that MM may be “flat” (neither long or short any shares). He fills the order and is now short 1,000 shares. He may raise his bid hoping to find a seller to “flatten” out his position. But before he realizes it a wave of buyers have come in and cleared out all the 50p offers. Now the stock is 50p bid 75p offered. Here comes that “Big” firm he just sold the 1,000 shares to at 50p with another bid for 1000 at 75p. He makes this print. Now he is short 2,000 at an average of .625. The market keeps moving and now its 75p bid 1.00 offered. Now he has to make a decision. Just like investors, MM Hate to take a loss. So 9 times out of 10 he will now sell 2000 at 1.00 making him short 4000 but with an average 81p. At this times he would love to see a seller at 75p so he can cover his short and make a few quid; but instead the market keeps moving up. Now it is 100p to 125p and here comes the buyer again at 125p. He doesn't want to lose the call so now he needs to sell 4,000 at 125p to keep his break-even point above the bid. Now he is short 8,000. Market moves up to 125p bid 15p0 offer here comes the buyer now he feels he must sell 8000 here because “stocks don't go up forever”. Now he is short 16,000. And so on and so on. If the stock keeps moving up, before he realizes it he could be short 50k or 100k shares (depending how big his bank is). Finally, the market closes for the day and on paper he may look all right in that his “break-even” price may be around the closing price. But now he has to figure out how to entice sellers so he can cover this short. It is important to note that if this happened to one MM it has probably happened to most all of them.

Some ways MM's entice sellers; Run the stock up with a “tight spread” in a fast market, then “open” up the spread to slow down the buying interest. After it has “cooled off” for a little while lower the offer below the last trade right after a small piece trades on the offer then tighten the spread so that the sellers feel they can take a “quick profit” by “hitting the bid” on the tight spread. Once the selling starts the MM's will walk it down quickly by only making small prints on the way down with the tight spread. Another way is by running the stock up in the morning, averaging up their short then use the above technique to walk it down in the afternoon. Hopefully after doing this for several days, it will demoralize the buyers. The volume will dry up and the sellers will materialize thinking that the game is over.

Contrary to popular opinion, MM usually Do Not Cover in Fast moving markets either Up or Down if they are short. They Short More. They usually try to cover after the frenzy is out of the market. There are many other techniques they use but the above are the most popular. This technique works about 9 times out of 10 particularly in a BB market. However, that is because 9 out of 10 BB stocks are BS. Remember what I said above. Most MM's don't have a clue as to the value of a Company until they get trapped. If the Company has solid fundamentals and a bright future. Then the stock will do very well. And the activity that caused the situation will prove to even help the future stock activity because it created an audience.”

Market Maker's Operating Procedure The savvy long-term investors never chase stocks up. For the most part that is momentum players and day traders where most of it or what follows is BBM money. If your desire is to make money and not become saddled with a BBM tag, you need to find a company that has been quietly getting on with its roll without making a song and dance with every ramptastic RNs. Typically, amped stocks will have several BB threads in their young life on AIM, for example. That is a red flag! Back on track…The savvy investors will once they have performed their due diligence, will accumulate and no amount of MM games will shake them. MM hate a stock that has a good core of long term investors not fearful of accumulating. Typically, a good solid company will have a spike, a retracement and a period of trading range. This is often a sign the MM is working a sell order into the market, yet there is a price pinch at which point the savvy long term holders continue to accumulate. The savvy investors are not interested in trading against the public mind or the BBM money. That's where the majority of the money can be made but even more can be made if the base of a stock is held extremely strong by investors.

Importance of Volume MMs follow a simple code of business when making a market in a stock. That is the level that stocks will seek that yields the most volume. Now this is very important because they make money on the volume buying at the bid and selling at the ask. In other words, by making the market they are buying low and selling high. Now smart money adheres to that rule, so do all the market makers. They could careless whether the stock is at 50p or 200p. All they care about is the action thus being able to sell stock at the offer (The high) and buy stock at the bid (The low). To increase their profitability, they make the spread as great as possible on as many shares as they can especially if the volume falls off.

When they have mostly all “buy” orders, that's not the price that's going to yield the most volume. They need both buy and sells to get the maximum action. Remember, MMs play the volume. If the volume decreases and there are mostly Buys that become a one-way volume, Buy volume. So what they do is let the stock run up to a price where it runs out of steam. They fill all the buy orders there that they can and then comes the pullback one way or another naturally or induced. Make no mistake, MMs know TA traders know where the resistance and support for a stock is and they WILL use this knowledge to relieve them of their stock if they need to cover a Buy side order. This will create the pull-back they can mop up the weak holders share and flip them to those averaging down or trying to catch the bounce. At some price, the stock will be relatively stable and yield the most volume.

Now that is the average price you will see The average price is the point where a stock seeks a level where MMs can profit on the most volume. So during the day that is the price that MMs and momentum/day traders want to see the stock at. Why? Because they know BBM money was chasing the price thing up. Most of the time, the MMs love a flurry of Market Orders which is a dead sign of an artificial run or momentum.

Tree Shake Shake the tree and watch the lemmings fall. This is a tactic often used to in an illiquid stock and low volume, which is often the case. If an MM has a buy order (outside normal market size) and no volume on the sell side, he will “shake the tree” to see if there are any weak holders about. This may be after a rally where buy pressure is still prevalent. MMs feel or rather know with some degree of certainty it is very likely BBM money will want to sell back those shares relatively quick on the slightest drop.

Now somewhat comfortable with this logic the MMs merely short sells into the buying and attempts to take the stock down in an effort to “shake out” the weak. Since it is tough to know for sure whether a move is the beginning of a trend, or a routine shake out, this type of deception works quite well for the MMs. What the long-termers do to a stock is surprise the MMs because instead of falling the shorting has no effect and the price goes up. Now that puts the MM at selling low through shorting and thus having to buy high in order to cover. And if it goes pear-shaped, the MM is caught short and the strength of the buy is overpowering the MM will want to cover his short position. So the MMs call up one of his friendly MMs and says some like “the weather is sure rough today.” The MM along with the other “friendly MM initiates a down tick about the same time. Now this can also be done with a certain amount of shares such as an infamous 100 shares flag. This down tick gives the illusion of weakness designed to hopefully begin the bear raid of selling. The fickle, fearful, day trader, momentum and short term begin to sell out allowing the MM to cover his short position at lower prices.

How to play their game, or NOT The most effective way to combat the MM manipulative game is to go long and become a long-term investor by slowly accumulating and holding thus drawing the MMs out of its defenses making them as naked as their short position. By managing your investment not overstretching your finances you do not become meat and drink for the MMs. No, use funds you can leave invested for the long haul, the battle, because ultimately, you are at war with the MMs and the BBM. Simply becoming a distressed seller make the life for the MMs much easier.

STRONG COMMERCIAL MOMENTUM BUILDING

Elric Lloyd-Langton April 7th 2018

Sometimes it's very difficult to keep up with events at OptiBiotix. Before we do, a factoid for you. NHS spend on treating obesity and diabetes is greater than the police, fire service and the judicial system combined!

If you were to look to the share price graph, it would suggest there is a funding issue, or there has been no progress by the BOD – In fact, you'd be forgiven for assuming the BOD have failed miserably over a two year period; they haven't and there is no funding issue. In truth, I think it is fair to say, with the benefit of hindsight, OptiBiotix perhaps got away from itself by December 2015 when the share price touched on the heady high of 103p. The fact is, OptiBiotix were back then, very much building an impressive IP bank, building the business from the foundation up to where it is now, the first floor of commercial progress. This metamorphosis from an R&D to a commercial entity only started eleven months ago at Vitafoods in Switzerland, where the company will again launch new products with one of it's largest partners, SACCO. There is anticipation a range of new LP-LDL® & SlimBiome® products will be launched soon, in-fact, the new corporate website has taken a metamorphosis of its own in preparation which will act as a central point for all stakeholders across the commercial, scientific and investment sectors wanting to find out more about the company’s developments and expertise. It's main focus will be B2B with B2c facilitating a retail arm for OptiBiotix's products and that of their partners.

OptiBiotix is now entering a key phase, it will be a year since it's first products were launched, by HLH BioPharma – the first of what group CEO, Stephen O'Hara calls small national type deals. Since then, in what must seem an eternity to long term investors, OptiBiotix has gone from strength to strength by signing increasingly larger commercial deals, ranging from raw ingredient manufacturers, formulators to distributors and sales.

Where are we now? Since May 2017, OptiBiotix have signed an average of one commercial deal per month. Most recent of these were with Trigen for OptiBiotix's own-label CholBiome™ products in South Asian markets and Cambridge Commonalities for SlimBiome® weight management technology, on a non-exclusive basis for the UK, or at least that is what many investors thought, so I asked SOH if he would clarify; “We build into any agreement the opportunity for any distributor to extend into new territories on a named customer basis. So if they came to us with a major retailer we would look to agree term on a named customer basis for that territory. This gives us maximum commercial scope without limiting further agreements in other territories.” Essentially, this means partners have the option to distribute throughout their commercial footprint on a named customer basis.

In a recent interview with Proactive Investors, SOH highlighted the point there is increasing interest from large pharmaceutical companies, and suggested it was a matter of time before OptiBiotix's IP was utilised in a pharmaceutical production, after all, all the IP is pharmaceutical based. But, there are two issues investors are struggling to understand, which has resulted in a two year negative trend in spite of real commercial progress with tight controls on the cash. 1: revenue visibility (more on that later). 2: The length of time a partnership result in tangible products. Currently (as far as we know) only HLH and 72% owned THWLC (GoFigure brand) have products on the shelves, so. I think it's fair to say many investors expected partner products to be available much quicker. The reality being, the partners have all grown in size, so has commercial footprint of these partners, so the logistics of other partners, like SACCO, Nutrilinea (earlier raw ingredient suppliers) need to manufacture the ingredients, then the process of market research and taste tests before production, all this can take 9-12 months for the larger partners like, Gallenicum, for example. Their commercial footprint for their “Stop & Go” probiotics spreads from Japan, Middle East, EU and Americas.

The revenue projections has been a real battleground on the forums, not helped with broker FinnCaps constant “corporate rating” non event....just say nothing guys. To be fair, they are waiting for guidance from SOH. Rightly or wrongly, SOH is being ultra-cautious, when the AIM market is rife with ramping statements from unscrupulous BOD's (usually ahead of a placing) some OptiBiotix PI's would perhaps like SOH to forget all that at and big the company up a little. In my opinion, SOH is being astute. The moment you start offering financial projections you are at the mercy of the partners and if those projections slip by 20% then a profit warning would need to be issued. That said, SOH has given us firm indications, approximate figures based on what the company has build thus far. Just because they have not appeared in an RNS, it doesn't make them less credible when the info is out there.

Revenues Back-end of last summer, SOH offered up the following in a conversation; “Our strategy is to build multiple partnerships and the £3-6m based on approx 10 national partnerships per application areas each delivering £300-£500K per year of existing products which comes from our discussions at Vitafoods, It does not include retail partnerships which in themselves can be worth £5-6m pa, or other application areas such as dairy, snack bars etc or partnerships with global corporates as these are more difficult to forecast both in terms of deal structure and timescale.”

It should be noted OptiBiotix have moved on since this comment, in that the national type deals appear to be taken over by the much larger deals, though I suspect we will get the c10 national type deals spread across all platforms. It is also worth noting the specific ref to “retail partnerships which in themselves can be worth £5-6m pa” given SOH's indication OptiBiotix have 3 lined up. Also another example, SOH indicated larger deals; TATA, Gallenicum, CII, and now I presume, FineFoods and Tigren could be worth c£1.5m +pa. “Both the OptiBiome® and OptiScreen® divisions have been set the target of breakeven this year and should have revenues of around £5m in a few years giving us a conservative valuation for each platform at £50m on a 10X multiple.” Continuing; “SBTX – of which we own 41.9% and the SweetBiotix® and microbiome modulation division will be valued higher. Investors may also have picked up that LP-LDL® is increasingly attracting interest from large pharma. The product has been develop using a pharma platform, has clinical studies equivalent to phase 1 and 2 and is increasingly be seen by partners as a biotherapeutic. This will greatly enhance the value of this asset. “

Let's think about this for a moment. OptiBiotix platforms are already equivalent to phase 1 and 2. Just the basic research time-frame can be anything from 3-6 years; that is a lot of time and funding saved right there, making OptiBiotix LP-LDL® very attractive, more so given the high profile pharmaceutical companies that have dropped their cholesterol hope, like Pfizer and more recently, Merck, citing its clinical trials were not good enough.

OptiBiome®: A high throughput technology platform that screens identifies and/or develops microbiome modulators, which can be used in proprietary formulations to prevent, manage, and a wide range of chronic lifestyle diseases. SlimBiome®, the first product commercialised, is used to manage weight to help ensure an individual’s health and wellbeing. Other products under development that help to improve human health through the science of the microbiome include:- I. CardioBiome® shown to reduce total cholesterol by 25% in gut models II. ImmunoBiome® is under development. Designed to improve immune health and reduce allergy symptoms III. PsychoBiome is under development. Designed to improve cognitive health and reduce anxiety and stress related conditions.

OptiScreen®: Targeted Probiotics A high throughput pharmaceutical screening platform to identify microbial metabolic pathways that interact with human pathways to improve health. OptiBiotix Health has developed a proprietary high throughput screening and optimisation technology platform designed to identify microbes with metabolic pathways that can interact with human physiological processes and derive health benefits.

The ProBiotic platform, could prove a much easier to predict revenues, because this tech is most likely going to be used to enhance existing probiotics, as demonstrated with Chr Hansen's LGG in collaboration with DSM. By using this to enhance existing probiotic products, it would by default have more predictable revenue recognition, because the sale data is historical and the royalties would be also. I think most of us forget about this platform and the size of it's existing market, which is growing rapidly. And given the recent headline about sugar content in some dairy products, this platform has the potential to be huge, and thus spun-out along with SweetBiotix. The scope here is huge, but it takes time.

Valuation benchmark We first need to understand the low cost business model. If this works well the company should be able to build up revenues in the £20-30m region in the future giving a valuation for OptiScreen division alone under current industry examples in the region of £200-300m. Perhaps this seems wishful. However, ProBi’s valuation of £500m (2016) value on £25m sales in 2015 accounts, or 20x revenues = industry valuations.” This is the model valuation I am using – right or wrong, so find your own benchmark that makes you comfortable.

I have commented on the Probi business model OptiBiotix is employing before in some detail, which can be seen here. It seems to me only seasoned long term investors understand the workings of what I believe is a brilliant strategy the wider market has not yet realised what is before them even as it unfolds. As well as the Probi business strategy, there is the company structure to consider.

Current commercial progress Broken down in to partnership value to OPTI. These are approximate figure based on the lower* end of anticipated progress. Built in are performance related targets designed to protect OPTI. I put the following to him this week, to which he answered, “looks right to me.” Brief and to the point.

Small – £300k + pa THWLC (GoFigure) HLH BioPharma PharmaBiota

Medium – £500k to £1m pa Nutrilinea Knightons Cambridge Commodities 

Large £1.5m + pa CII 2XTATA Tigren pharmaceuticals  FineFoods & Pharmaceuticals Plus as yet two unknown **US partners; One took shipment of one ton of SlimBiome® for trial purposes and the other SACCO brought to the table for LP-LDL® which I think is for dairy products.

SOH has also spoken of three large UK Retails, these could yield **£5m – £6m pa, but at reduced margins. In addition, it is hoped the new e-commerce site will in time represent 10-12% of group revenues and become a business in it's own right.

If we concentrate on the lower estimates* we have for confirmed partners, we arrive at a figure of c£11.9m revenues. This is forward looking with 12 months of revenues from all existing partnerships, by FY 2019, being the most realistic time-frame. Using the 20 x revenue multiple, I arrive at a market cap of c£236m, ex £2m PLC costs attributed additional to the new **e-commerce site **Not included in estimated revenues.

The other noteworthy, is operating margins. Prob's are not so great compared to OPTI. According to stockcube comparison tool, 2017 GROSS MARGINS were under 50%. See http://tinyurl.com/y7pulkl7 I have no idea how accurate this tool is and I haven't done the maths myself either, but we do know OptiBiotix's GROSS MARGINS are considerably greater than Probi's – so, in time I wouldn't be surprised if OptiBiotix's earning multiple was double or even more than Probi's. Just not yet though! The reason for the huge difference between OptiBiotix v Probi's margins is down to one difference in the business model; OptiBiotix is essentially a virtual company, Probi is not because it has a manufacture facility. Dependent on quantities of whatever it needs to manufacture, it does so in-house – OptiBiotix is out-of-house via CII, SACCO, Knightons & DSM, ALL 50/50 profit share on supply of ingredients. Furthermore, partners like SACCO undertake further scientific studies to prove up the science even further at no additional cost to OptiBiotix.

Near term revenues will come from SACCO, CII, Nutrilinea, Knighton and DSM, because these companies will provide the raw ingredients for products, which will be invoiced and paid for on delivery. Royalties and profit share later.

IMHO, SOH will have an indication of product sales based on ingredients weight supplied, and in most cases, he should have a good indication by interims 2018 and perhaps he may feel confident in offering guidance at the FY report in April/May 2019. That said, it is likely SOH would be tempted to keep a lid on expectations until most contracts have had 12 months under their belt. I see nothing wrong with this tactic, though understand investors want as much detail as possible. However, this needs to be balanced within the terms of NDA's – respect, trust builds confidence and a strong business relationship.

Commercial retail hoops I'm like so many investors here, I just don't fully understand the mechanic of what management do behind the scenes. Yes I imagine time consuming negotiations, legal documents, etc. OptiBiotix are in a very good position as first movers in key healthcare area's within the humanbiome and their technology is highly sort after. This causes it's own problems, in that you may have multiple companies wanting exclusivity over in terms of territory, or product(s), this is a nice problem to have, but it slows the whole process down as OptiBiotix BOD try to strike the right long term deal. The consequence of this, OptiBiotix get the deal that is right for them without compromising on strategy and costs.

Christina gave a very useful insight to the work she had to do and the payback, which I imagine many of us will not have been aware of, unless they had a background in retail purchasing, etc. On the SlimBiome® front, I have been very active putting the right foundations in place ready for a big commercial push in 2018, including working on applications, product development and process improvement with the right partners. As I am from a food manufacturing background, I know what is needed by retailers so had to put some ‘rigour’ into our process by introducing the necessary governance, traceability, trials and gate approval systems for best products/ingredients/manufacturers ready for listings. Our new improved SlimBiome® is now ready and has opened up a lot of new opportunities and possibilities as we can include it in much wider range of products without affecting its functionality. All that takes time but it was well worth investing in it to get it right ready for commercialisation. We ran some trials which were very successful and gave a much better end product than using the original SlimBiome® as well as improving the mouthfeel and texture. There’s also a lot on GoFigure but I cannot go into detail until our next RNS.   To get listed in any major retail outlet, there are only 2 range reviews per year and a product approval system to go through prior to getting products on the shelves. This can take many months as they want to check products, regulatory, store trials before finally giving the ‘green light’. There is also a lot of testing from our side to see how the products respond to different temperatures and humidities , (in the case of exporting) shelf life trials (how does the product degrade over time), micro’s testing (is there any danger of microbial growth over time) – all of which takes time and investment.

Summary observations The current share price fluctuations are part of a trend we have seen a few times over the last 12 months where market makers and some traders selectively pick out a couple of areas to panic/concern investors to put download pressure on the price. History tells us that the price typically bounces back as the fundamentals on which the business has been built have not changes. These are:-   1. OptiBiotix are leading the field in the microbiome space, a market growing at 22.3% per year, and described by health experts as ‘healthcare’s most promising and lucrative frontier’. Recent corporate visits to the US and across Europe added further reassurance to BOD's belief that they have world leading technology which is exciting the interest of major corporates. 2.  The company has been built on four platforms: SkinBiotherapeutics (of which OPTI owns 42%), OptiBiome (of which SlimBiome® is one product), Optiscreen® (where they have launched LP-LDL®) and OptiBiotics® (which includes microbiome modulators). These diversify investor risk and create multiple opportunities across major markets. We believe we are unique in capturing such a wide breadth of opportunities in the microbiome space. 3.  In the last 3 years the company has created new science, tested it in the laboratory, and then performed clinical studies, so we can be assured we have safe and effective products. Products have won international awards and we have won awards for best science at major scientific events in both 2017 and 2018. This demonstrates the leading nature of both the science and products. OptiBiotix now have world leading key opinion leaders presenting its science for them which creates corporate interest. This is all part of building a strong and valuable business. 4.  The strategy has been clearly defined from the beginning: develop the science, strike joint development deals with global partners, prove the science in humans studies, and then strike deals with manufacturers, formulators, and distributors to commercialise the products. This is a track I have gone down many times and builds true value.  5. OptiBiotix have struck deals with major corporate partners such as Tata (x2) and DSM (the worlds largest ingredient supplier) to either manufacture product on a global scale or develop applications for themselves consistent with a JV and JDA strategy.  NDA's means confidentiality not to disclose the launch plans of these companies as because of the “intel inside” and not the product owner. 6. Rapidly transitioning from a product development company to the commercial stage of the companies development. This started in Europe in May 2017 and USA in late September. Since then been a rich deal pipeline has been developing which will build into significant revenues over time. The plan is for each divisions building revenues of between £5-£10m in the forthcoming years giving valuations for each division of £50 to £100m. Most investors will have seen from the recent RNS’s the gradual evolution from small privately owned pharma companies to larger £100m + revenue companies like Cereal Ingredients and Gallenicum. OPTI will continue on this path as it reduces the dependency on one or two big deals but has to be negotiated carefully so as not to exclude the global opportunity. 7. OptiBiotix are in a new space with new partners I believe providing revenue forecasts is high risk until the completed commercial transition. However, SOH has often provided guidance on likely deal contributions...see above. 8. Typical commercial deals should generate annual revenue in the £250,000 – £500,000 range for smaller privately owned companies with deals with companies with £100m + revenues typically worth £750k-£1.25m pa, as well as anticipation of larger deals in the multi-million range with global corporates and large retailers. 9. On AIM there is often a disconnect between the scale of opportunity and the share price which can often be artificially manipulated (higher or lower) with a number of trades. However, as outlined in the most recent proactive interview investors should be able to see they are building commercial momentum across all our platforms, starting with the smaller deals with pharma groups which are quicker to execute and building into larger deals with the likes of Cereal Ingredients, Gallenicum, and FineFoods. This trend looks as though it will continue interspersed with a number of corporate and retail deals in the pipeline. 10. I feel we are close to the wider market realising both LP-LDL® and SlimBiome® have already built up multiple revenue streams, possibly greater than we initially envisaged. Once this becomes fact, then each new partnership announced will have a material effect on the share price. 11. Opportunities to close out 3 major retailers, six major corporates, including 2 global corporates for SweetBiotix® 12. Online site at the end of April selling a wide range of products being developed by our partners.

The signs are there, you just need to look What followed was one of the biggest confirmation signposts yet OptiBiotix are gaining significant commercial traction in the US and Europe, with the building of new pharma ready production capacity (FineFoods (12000 sqm), CSL & SACCO combined 3700 sqm) in US and Europe and confirmation from our CEO, OptiBiotix is key to this development. Of course, there is the usual caveats here; OptiBiotix are not CSL & SACCO's only client and I'm sure any new corporate would want assurances any business they give them, they have the capacity to supply them. Either way you look at this development, it is great news, but how far out there beyond existing investors has it got?

What we need is an RNS stating; due to commercial demand for a number of OPTI wellbeing products, two of the global leaders in the manufacturing capabilities have invested in the expansion of pharma ready and FDA approved production capacity in the US and Europe to ensure they can assure their clients they can meet increasing demands for the products containing OptiBiotix, LP-LDL®, the “intel inside” their dairy and other food products. And of course, commercial contracts that eat up this capacity.

SOH's thoughts after SACCO tweet and comment from me. He offered the following, which confirms my thoughts, hopes, I guess would be more accurate.

SACCO are an excellent partner who have invested heavily (£1m) in supporting LP-LDL given us booth time at major exhibitions and employing new staff to take the product across Europe, and the USA, and take the dairy product to Asia. THE INCREASED CAPACITY IS A REFLECTION OF THE INTEREST IN LP-LDL and OTHER OPPORTUNITIES BEING DEVELOPED BY OPTIBIOTIX, and Sacco reputation and expertise. We had numerous opportunities to work with global manufacturers but chose SACCO/CSL for their industry reputation, extensive network and track record in building sales. We believe we have made the right choice.

We are seeing a similar commitment from Cereal Ingredients which we believe will pay major dividends in the US market.

I hope this type of news helps build the picture for investors of our commercial strategy whereby we strike partner agreements with manufacturers, formulators, and distributors taking a percentage of each part of the value chain to give us multiple revenue streams form multiple partners across multiple territories. This is unlike any other company who tend to focus on a single technology, single product platform, but is designed to mitigate risk and build a £200m+ business.

We started on the commercialisation path in May (Europe) last year for SlimBiome® and LP-LDL® but investors should not forget that whilst lst SlimBiome® and LP-LDL® are starting to build sales their are large opportunities with microbiome modulators, OptiBiotics®, SweetBiotix®, and of course SBTX. I believe any one of these has the potential to be a £60m business in its own right. As you have identified anyone reading the SBTX report should be able to see the potential opportunity for SBTX and recent rises in the share price would seem to support this. Manufacturing scale up, the data on Staph aureus, are significant milestones which with a an upcoming clinical study should lead to a significant value enhancement.

The author of this report has a financial interest in Optibiotix Health PLC and SkinBioTherapeutics PLC as a shareholder.

The contents of this reports is for educational and information purposes only. No advice is intended.

Elric Lloyd-Langton April 9th 2018

NANO is a UK-based nanotechnology company that spun out from the research group of Prof. Paul O’Brien at the University of Manchester in 2001. The company’s development has been driven by Dr Nigel Pickett, Nanoco’s Chief Technology Officer, whose pioneering work on the patented “molecular seeding” process has formed the basis of NANO’s unique technology, and Dr Michael Edelman, who joined NANO as CEO in 2004, leading the company’s growth from a two-man start-up to a publicly traded organisation with more than 120 employees across the globe. More recently, NANO appointed David Yao as Senior Vice President of Global Sales. Yao has a track record of generating worldwide sales is perfectly aligned with NANO's growth ambitions.

NANO was selected out 130 companies as the winner of the prestigious Prism Awards 2016 in the Materials and Coatings category for its cadmium-free CFQD® quantum dots, at the time seen as a breakthrough in non-toxic, cadmium free quantum dots as an enabling technology transforming a broad range of applications including display, lighting, biomedicine and solar. Back in August 2017 the European Commission announced it is to Prohibit Cadmium from TVs and Displays by October 2019, since this announcement, NANO have noticed display manufacturers move away from Cadmium problem, particularly OEM's in China.

The main focus of this article will be NANO's display market because at least in the near term, it is where the bulk of the revenues will be arriving from, but it should be noted, NANO have effectively four divisions within the group as follows;

CFQD® Technology NANO's business structure is formed around the key area's in; displays, lighting, solar and bio-imaging.

INVESTMENT HIGHLIGHTS

• A pioneer in the development and production of CFQD® cadmium-free quantum dots • Scaleable “platform technology” with multiple markets and product applications • Cost and performance competitive versus OLED technology • Key target markets are display, lighting, bio imaging and solar • Supply and licensing agreements in place with Dow, Merck and Wah Hong position Nanoco to dominate the markets and drive revenue growth • LCD TV market starting to ramp usage of cadmium-free quantum dots with market leader Samsung leading the way with its SUHD TV range • Extensive and growing patent portfolio • World leader in heavy metal free quantum dots • Unique “seeding process” enables mass production • Bright and energy efficient • Highly tunable to emit a specific colour on the spectrum • Quantum dot surface can be chemically modified for different end use applications, creating a “platform technology” • Extensive & growing patent portfolio (c. 500 patents and patent applications) covering five key areas: Process, Materials, Surface Chemistry, Solar & Devices

Revenue model NANO licensing model works via a mix of upfront & milestone payments, quarterly royalty payments – It is these royalty payments which are expected to start filtering into the bottom-line starting Q1 2018.

DOW CHEMICAL • Announced January 2013; modified March 2016 • Changed from exclusive to non-exclusive in March 2016 • Non-exclusive worldwide technology licensing agreement with royalty payments

WAH HONG • Announced July 2016 • 7 year non-exclusive material supply and licence agreement with upfront licence fee, payment for delivery of QD resin and royalties on sales

MERCK KGaA • Announced August 2016 • Non-exclusive material supply and licence • Agreement with upfront licence fee, royalties on sales of Merck produced product • Ability for Merck to purchase Nanoco manufactured product to accelerate their market entry

Have the bears had their fill? So, is the time right now for NANO as a viable commercial company, one that investors should trust to appreciate in market value? I cannot say yes to the latter because I'm not FCA regulated, and this article only serves to offer research material. That said, I'm invested and have been for some time. To the former, the shadow hanging over NANO has always been funding, as is always the case with pre-commercial companies trying to find their place in the commercial world, and of course the ambition to transition from an R&D company to one of a viable commercial company that has something to offer the World – to this end, NANO's technology has never been in doubt, just its cash balance; will it run out of money before break-even? The question related to funding will not worry the bears at this stage, though the appetite for shorting will be less so in due course. Last Octobers raised £8.6m via a sightly discounted placing to which all the BOD took part in – some with what I would call token gestures, while others x3 token. In any event, all appear to be geniuses given their 18p stake. More encouraging – NANO reported reduced losses as well as additional reduction of PLC costs of c£400k per month and running at a more acceptable level of c£700k pm Even so there isn't much headroom between now and the need for serious cash inflow from the ramp-up of commercial orders. The key aspect here is the fact NANO have significantly increased their Runcorn production capacity and with the aid of an unnamed US partnership paying to increase the manufacturing capacity at the group’s Runcorn facility and will start ordering products in early 2019 – there should be even less strain on the cash.

It should also be noted the downward pressure on the SP has not just been the bears feasting, but II selling down their holding; Baillie Gifford being the most recent II, dumping 4.2% of its 9% holding in March. Have they finished?

Hit the reset – commercial partnerships NANO have removed the DOW exclusive shackles, thus allowing the company to negotiate non exclusive multi-channel commercial approach, thus less reliant on one dominant company. This is not to say DOW have walked away, they are very much aligned in business. However, there has been a negative consequence to the new arrangement with DOW, in-as-much as NANO are now dealing directly with display manufacturers, rather than DOW on their behalf. This has resulted in slower commercial process because NANO had a steep learning curve in getting it's technology evaluated, accepted and fine tune to partners needs....something I touched on earlier. However, ultimately, NANO will see material benefit and become masters of their own destiny. NANO is expecting a significant up tick in orders in Q1 2018, most likely from Chinese based AUO, whom will have NANO technology in a commercial sense, on sale for their gaming display market. However, NANO has no control on timing of sales. AUO had a number of their high end new 65inch to 85inch displays on show at a recent Asian trade show.

German display manufacture, Merck will continue to be supplied by the Runcorn facility until it has it's own manufacturing facility in production.

Competition Surprisingly, there isn't a great deal. The global players are NANO partners, DOW and Merch, whom can deliver true CFQD® Technology and NANO. OK, not quite sewn up – there is US corp Nanosyse, they are a hybrid CFQD, so not true CFQD® Technology competitor. Samsung have their own in-house

Displays They key focus is NANO's ability to supply industrial quantities of cadmium free options for the display markets, which appears to be where investor excitement is, no doubt because of the advantages NANO's technology has over older LCD, and some OLED technology and of course, the outlawing of the heavy metal cadmium, which was used in displays for its red, orange and yellow properties, which gave display bright and vibrant colours. However, it's limited in scope – the larger the display surface the less vibrant the colours. That aside, the real issue for cadmium, is it's long-term exposure to cadmium can cause adverse health effects,” according to the official recall notice from the CPSC. A known carcinogen, or cancer-causing agent, chronic cadmium exposure has been shown to primarily cause severe kidney problems, including kidney failure, and, secondarily, bone softening. Hence the World over governments are clamping down of it's use. NANO's solution is known as CFQD® quantum dots offer enhanced colour, energy efficiency, and seamless integration into existing production processes. This technological advance not only makes displays safer, colours more vibrant, displays are much larger then their OLED counter parts, with no loss colour of vibrancy.

NANO's quantum dots, incorporated into a film located in between the LED light source and the LCD panel, are “excited” by light emitted from blue LEDs, transforming some of it into very pure green and red light. Due to this, the LCD panel receives a richer white light and expands the range of colour that the display can reproduce. To the viewer, the difference is significant: reds are deeper, greens are brighter, the entire colour palate is rendered with unprecedented vividness, bringing the imaged world vibrantly to life.

The chemical processing enables production of quantum dots at precisely defined sizes, Because the size dictates the colour they emit, quantum dots can be finely tuned to meet specifications for optimal display performance. NANO’s unique scalable production processes enables the manufacture of heavy-metal free quantum dots in large volumes. As legislation restricting the use of heavy-metals gets ever tighter, CFQD® quantum dots are uniquely positioned as the future-proof quantum dot display technology on the market.

Transitioning from R&D to Commercial July 2017 NANO announced it had received its first commercial order from Wah Hong Industrial, a Taiwan-based manufacturer of optical films and sheets for the display industry, for the supply of resins containing NANO’s cadmium-free quantum dots (CFQD). NANO says  its CFQD technology is now being evaluated in 16 active TV and monitor programmes with 13 major OEMs. This followed an earlier agreement with Kyulux Inc, to Develop Next Generation Displays Cadmium-Free Quantum Dot Hybrid QLED – OLED Technology.

Kyulux may well not be a household name in the display market, hence why investors didn't appear to to excited about this deal. However, it's worth drawing your attention to the about section of the RNS on 22nd May 2017; Kyulux is a leader in developing and delivering the next generation of organic light emitting diode (OLED) technology, TADF. Kyulux develops and sells TADF and Hyperfluoresence based OLED materials and solutions to manufacturers in the display and lighting industries. Founded in 2015, the Company currently owns or has exclusive, co-exclusive or sole license rights to a large TADF intellectual property portfolio developed over the past seven years at Kyushu University and its industrial partners. Kyulux also enjoys a license to cutting-edge deep learning-based artificial intelligence technology for chemical discovery developed at Harvard University.

Kyulux's co-founder and the inventor of TADF technology, Prof. Chihaya Adachi, is widely viewed as the top global researcher in OLED technology, having been a key author and inventor in all previous generations of OLED materials that are now used everyday by consumers across the globe. This all seems a very good strategic move on NANO's part, which is often missed by investors in absence of heady share price movements.

Patience is a virtue Many PI's have unrealistic expectations of a company's transition from R&D to commercial, failing to understand potential partnerships take time and care to develop – typically, wrapped in NDA's, this often creates the illusion nothing is happening when there are prolong periods of radio silence. Before even brokering any type of deal, NANO will have to spend time and money of protecting their technology with IP & TM in various regions. Even then, it is likely potential partners will attempt to see if they can circumvent these, if only to test the resolve and of course, their partnership. Then we are into the realms of viability – New technological advances need tooling adjustments for the manufacturer, this takes time and often at a considerable cost to the partner. Then there is the DD and product testing. C. P. Yeh, President of Wah Hong Industrial gives us a little insight on this front; “As a business, we recently invested in a new, wider coating line that will enable films large enough to fit 100 inch TVs to be produced and we remain on track to commence production of CFQD films for our customers during the second half of 2017.”

“This represents a significant milestone for our business and justification of the commercial potential for NANO’s cadmium-free quantum dot technology in the international display industry,” says Michael Edelman, CEO of NANO. “We are confident that the scale of orders should increase over the coming months. In light of increasing global regulations restricting the use of cadmium, including the imminent ban by the European Commission of cadmium in display products, manufacturers across the world are seeking more sustainable solutions that still deliver outstanding colour performance.”

The short version would be c12 months from initial corporate engagement to products of products. This seems to be typical no matter the sector you are partnering in. This is the very same point I have been making with other companies I have an investment interest in; namely, OptiBiotix (OPTI) SkinBioTheraputic (SBTX).

Lighting NANO's lighting technology has evolved, LED lighting – bright, high-efficiency and long-lasting – is well placed to become the light source of the future. Most most LED lighting technology offers lower colour performance relative to incandescent light and fails to show the true colour of illuminated objects. The primary focus is horticulture. For example, it has been accepted for quite some time Using LEDs for plant growth lights is very beneficial to plant life, however, the use of QD lighting is proved even more beneficial. With NANO's CFQD® cadmium-free quantum dot LED grow lighting systems, it is apparent there is a significant advantage of traditional LED lighting, because it optimizes the light spectrum for plant growth.

NANO’s CFQD® quantum dots offer a simple and effective solution that can both tune the colour and improve the quality of light. Since the materials are free from toxic cadmium and heavy-metals, they can readily be used in lighting and device applications. Bio-imaging Typically, medical imaging is performed using fluorescent dyes as a powerful tool for the diagnosis and treatment of diseases. However, the fluorescent dyes currently used offer poor photostability, with narrow absorption spectra (requiring excitation at a precise wavelength) and/or weak fluorescence due to low extinction coefficients. The development of fluorescence imaging agents using QDs may pave the way for new medical imaging techniques. QDs offer a number of advantageous properties for fluorescence imaging, including high photostability, broad absorption spectra, narrow, symmetric and tunable emission spectra, slow excited state decay rates and high extinction coefficient resulting in strong fluorescence.

05 July 2017, NANO was Awarded Grant of from Innovate UK for Major Life Sciences Project to support its ongoing research into the use of quantum dot nanoparticles within cancer imaging.

The research project which has received the grant – entitled “VIVODOTS™ nano-devices for detection, resection and management of pancreatic cancers” – is a continued collaboration between NANO and University College London (“UCL”), the Group's partner in the life sciences sector, and builds on the significant progress that NANO's Life Sciences team has made on in-vivo mapping of sentinel lymph nodes and breast cancer imaging. In support of the project, NANO will receive grant funding from Innovate UK of up to £484,689, representing 60% of the costs the Group expects to incur, paid quarterly in arrears over a three-year period.

The proposed VIVODOTS™ nano-device will enable more effective pre, intra and post-operative management of pancreatic cancers, resulting in better surgical treatment, higher cure rates, and better quality of life for survivors. Later development should lead to the extrapolation of the same concept to other types of deadly malignancies.

The author of this report has a financial interest in Nanoco PLC. The contents of this reports is for educational and information purposes only.

No advice is intended.